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Time-resolved, single-molecule, correlated chemical probing of RNA

Capturing the folding dynamics of large, functionally important RNAs has relied primarily on global measurements of structure or on per-nucleotide chemical probing. These approaches infer, but do not directly measure, through-space structural interactions. Here we introduce trimethyloxonium (TMO) as...

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Pubblicato in:J Am Chem Soc
Autori principali: Ehrhardt, Jeffrey E., Weeks, Kevin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917579/
https://ncbi.nlm.nih.gov/pubmed/33095984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c06221
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