SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability

SPOP is one of the important subunits for CUL3/SPOP/RBX1 complex tightly connected with tumorigenesis. However, its exact roles in different cancers remain debatable. Here, we identify CYCLIN E1, as a novel substrate for SPOP. SPOP directly interacts with CYCLIN E1 and specific regulates its stabili...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cell Death Differ
Hlavní autoři: Ju, Lin-Gao, Zhu, Yuan, Long, Qiao-Yun, Li, Xue-Jing, Lin, Xiang, Tang, Shan-Bo, Yin, Lei, Xiao, Yu, Wang, Xing-Huan, Li, Lianyun, Zhang, Lei, Wu, Min
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748103/
https://ncbi.nlm.nih.gov/pubmed/30237511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0198-0
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky