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SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG
Speckle-type POZ domain protein (SPOP), an adaptor in the E3 ubiquitin ligase complex, recognizes substrates and promotes protein degradation via the ubiquitin-proteasome system. It appears to help regulate progression of several cancers, and we show here that it acts as a tumor suppressor in pancre...
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| 出版年: | Cell Death Dis |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6797744/ https://ncbi.nlm.nih.gov/pubmed/31624231 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2017-z |
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