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TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

TRIM24 is an effector substrate of the E3 ubiquitin ligase adaptor SPOP and becomes stabilized in prostate cancer (PCa) with SPOP mutations. However, how TRIM24 protein is regulated in the vast majority of SPOP-wildtype PCa is unknown. Here we report TRIM28 as a critical upstream regulator of TRIM24...

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Detalles Bibliográficos
Publicado en:Nat Commun
Main Authors: Fong, Ka-wing, Zhao, Jonathan C., Song, Bing, Zheng, Bin, Yu, Jindan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6258673/
https://ncbi.nlm.nih.gov/pubmed/30479348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07475-5
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