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Prax330 Reduces Persistent and Resurgent Sodium Channel Currents and Neuronal Hyperexcitability of Subiculum Neurons in a Mouse Model of SCN8A Epileptic Encephalopathy.
SCN8A epileptic encephalopathy is a severe genetic epilepsy syndrome caused by de novo gain-of-function mutations of SCN8A encoding the voltage-gated sodium (Na) channel (VGSC) Na(V)1.6. Therapeutic management is difficult in many patients, leading to uncontrolled seizures and risk of sudden unexpec...
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| Publicado no: | Neuropharmacology |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6745260/ https://ncbi.nlm.nih.gov/pubmed/31278928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.107699 |
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