Prax330 Reduces Persistent and Resurgent Sodium Channel Currents and Neuronal Hyperexcitability of Subiculum Neurons in a Mouse Model of SCN8A Epileptic Encephalopathy.

SCN8A epileptic encephalopathy is a severe genetic epilepsy syndrome caused by de novo gain-of-function mutations of SCN8A encoding the voltage-gated sodium (Na) channel (VGSC) Na(V)1.6. Therapeutic management is difficult in many patients, leading to uncontrolled seizures and risk of sudden unexpec...

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Publié dans:Neuropharmacology
Auteurs principaux: Wengert, Eric R., Saga, Anusha U., Panchal, Payal S., Barker, Bryan S., Patel, Manoj K.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745260/
https://ncbi.nlm.nih.gov/pubmed/31278928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.107699
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