19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension

19-Hydroxyeicosatetraenoic acid (19-HETE, 1), a metabolically and chemically labile cytochrome P450 eicosanoid, has diverse biological activities including antagonism of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE, 2). A SAR study was conducted to develop robust analogs of 1 with im...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Dakarapu, Rambabu, Errabelli, Ramu, Manthati, Vijaya L., Adebesin, Adeniyi Michael, Barma, Deb K., Barma, Deepan, Garcia, Victor, Zhang, Fan, Schwartzman, Michal Laniado, Falck, John R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745249/
https://ncbi.nlm.nih.gov/pubmed/31439380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.08.020
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