19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension

19-Hydroxyeicosatetraenoic acid (19-HETE, 1), a metabolically and chemically labile cytochrome P450 eicosanoid, has diverse biological activities including antagonism of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE, 2). A SAR study was conducted to develop robust analogs of 1 with im...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Main Authors: Dakarapu, Rambabu, Errabelli, Ramu, Manthati, Vijaya L., Adebesin, Adeniyi Michael, Barma, Deb K., Barma, Deepan, Garcia, Victor, Zhang, Fan, Schwartzman, Michal Laniado, Falck, John R.
Formato: Artigo
Idioma:Inglês
Publicado: 2019
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745249/
https://ncbi.nlm.nih.gov/pubmed/31439380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.08.020
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares