Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

The ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1(K376R) which is defective in RIPK1 ubiquitination die during embryogenesis. This lethality is ful...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Zhang, Xixi, Zhang, Haiwei, Xu, Chengxian, Li, Xiaoming, Li, Ming, Wu, Xiaoxia, Pu, Wenjuan, Zhou, Bin, Wang, Haikun, Li, Dali, Ding, Qiurong, Ying, Hao, Wang, Hui, Zhang, Haibing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744433/
https://ncbi.nlm.nih.gov/pubmed/31519886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11839-w
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