Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

The ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1(K376R) which is defective in RIPK1 ubiquitination die during embryogenesis. This lethality is ful...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Zhang, Xixi, Zhang, Haiwei, Xu, Chengxian, Li, Xiaoming, Li, Ming, Wu, Xiaoxia, Pu, Wenjuan, Zhou, Bin, Wang, Haikun, Li, Dali, Ding, Qiurong, Ying, Hao, Wang, Hui, Zhang, Haibing
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744433/
https://ncbi.nlm.nih.gov/pubmed/31519886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11839-w
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