Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis

The ubiquitination status of RIPK1 is considered to be critical for cell fate determination. However, the in vivo role for RIPK1 ubiquitination remains undefined. Here we show that mice expressing RIPK1(K376R) which is defective in RIPK1 ubiquitination die during embryogenesis. This lethality is ful...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Zhang, Xixi, Zhang, Haiwei, Xu, Chengxian, Li, Xiaoming, Li, Ming, Wu, Xiaoxia, Pu, Wenjuan, Zhou, Bin, Wang, Haikun, Li, Dali, Ding, Qiurong, Ying, Hao, Wang, Hui, Zhang, Haibing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744433/
https://ncbi.nlm.nih.gov/pubmed/31519886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11839-w
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