RIP1 kinase activity-dependent roles in embryonic development of Fadd-deficient mice

RIP1 is an essential regulator of TNF-induced signaling complexes mediating NF-κB activation, apoptosis and necroptosis. Loss of Rip1 rescues the embryonic lethality of Fadd or Caspase-8-deficient mice, even though the double knockout mice die shortly after birth like Rip1-deficient mice. Recent stu...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Liu, Yongbo, Fan, Cunxian, Zhang, Yifan, Yu, Xianjun, Wu, Xiaoxia, Zhang, Xixi, Zhao, Qun, Zhang, Haiwei, Xie, Qun, Li, Ming, Li, Xiaoming, Ding, Qiurong, Ying, Hao, Li, Dali, Zhang, Haibing
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520462/
https://ncbi.nlm.nih.gov/pubmed/28574501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.78
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