MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome

MLKL, a key component downstream of RIPK3, is suggested to be a terminal executor of necroptosis. Genetic studies have revealed that Ripk3 ablation rescues embryonic lethality in Fadd- or Caspase-8-deficient mice. Given that RIPK3 has also been implicated in non-necroptotic pathways including apopto...

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Pubblicato in:Cell Rep
Autori principali: Zhang, Xixi, Fan, Cunxian, Zhang, Haiwei, Zhao, Qun, Liu, Yongbo, Xu, Chengxian, Xie, Qun, Wu, Xiaoxia, Yu, Xianjun, Zhang, Jianke, Zhang, Haibing
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191534/
https://ncbi.nlm.nih.gov/pubmed/27498868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.103
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