Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation

Celastrol exhibits potential anti-inflammatory activity in a variety of inflammatory diseases, but the mechanism remains poorly understood. Activation of NLRP3 inflammasome is involved in multiple inflammatory diseases. Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibi...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Yu, Xianjun, Zhao, Qun, Zhang, Xixi, Zhang, Haiwei, Liu, Yongbo, Wu, Xiaoxia, Li, Ming, Li, Xiaoming, Zhang, Jingxuan, Ruan, Xuzhi, Zhang, Haibing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620174/
https://ncbi.nlm.nih.gov/pubmed/28978034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18619
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