Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation

Celastrol exhibits potential anti-inflammatory activity in a variety of inflammatory diseases, but the mechanism remains poorly understood. Activation of NLRP3 inflammasome is involved in multiple inflammatory diseases. Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yu, Xianjun, Zhao, Qun, Zhang, Xixi, Zhang, Haiwei, Liu, Yongbo, Wu, Xiaoxia, Li, Ming, Li, Xiaoming, Zhang, Jingxuan, Ruan, Xuzhi, Zhang, Haibing
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620174/
https://ncbi.nlm.nih.gov/pubmed/28978034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18619
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