Celastrol ameliorates inflammation through inhibition of NLRP3 inflammasome activation

Celastrol exhibits potential anti-inflammatory activity in a variety of inflammatory diseases, but the mechanism remains poorly understood. Activation of NLRP3 inflammasome is involved in multiple inflammatory diseases. Here, we show that celastrol abolishes the NLRP3 inflammasome activation, inhibi...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Yu, Xianjun, Zhao, Qun, Zhang, Xixi, Zhang, Haiwei, Liu, Yongbo, Wu, Xiaoxia, Li, Ming, Li, Xiaoming, Zhang, Jingxuan, Ruan, Xuzhi, Zhang, Haibing
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620174/
https://ncbi.nlm.nih.gov/pubmed/28978034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18619
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