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Evidence for Internal Initiation of RNA Synthesis by the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B In Cellulo

Initiation of RNA synthesis by the hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) NS5B has been extensively studied in vitro and in cellulo. Intracellular replication is thought to rely exclusively on terminal de novo initiation, as it conserves all genetic information of the genome. In...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Schult, Philipp, Nattermann, Maren, Lauber, Chris, Seitz, Stefan, Lohmann, Volker
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744235/
https://ncbi.nlm.nih.gov/pubmed/31315989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00525-19
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