Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation

The flavivirus NS5 is a natural fusion of a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Analogous to DNA-dependent RNA polymerases, the NS5 polymerase initiates RNA synthesis through a de novo mechanism and then makes a transition to a processive elongation phase. However,...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Wu, Jiqin, Lu, Guoliang, Zhang, Bo, Gong, Peng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Genome Replication and Regulation of Viral Gene Expression
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301151/
https://ncbi.nlm.nih.gov/pubmed/25320292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02085-14
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