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The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication
The flavivirus NS5 harbors both a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Both enzyme activities of NS5 are critical for viral replication. Recently, the full-length NS5 crystal structure of Japanese encephalitis virus reveals a conserved MTase-RdRP interface that featu...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Public Library of Science
2014
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4031075/ https://ncbi.nlm.nih.gov/pubmed/24852307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002891 |
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