Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication

The spread of Zika virus (ZIKV) has caused an international health emergency due to its ability to cause microcephaly in infants. Yet, our knowledge of how ZIKV replicates at the molecular level is limited. For example, how the non-structural protein 5 (NS5) performs replication, and in particular w...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Rusanov, Timur, Kent, Tatiana, Saeed, Mohsan, Hoang, Trung M., Thomas, Crystal, Rice, Charles M., Pomerantz, Richard T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6255901/
https://ncbi.nlm.nih.gov/pubmed/30478404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35511-3
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