The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

The flavivirus NS5 harbors both a methyltransferase (MTase) and an RNA-dependent RNA polymerase (RdRP). Both enzyme activities of NS5 are critical for viral replication. Recently, the full-length NS5 crystal structure of Japanese encephalitis virus reveals a conserved MTase-RdRP interface that featu...

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Hlavní autoři: Li, Xiao-Dan, Shan, Chao, Deng, Cheng-Lin, Ye, Han-Qing, Shi, Pei-Yong, Yuan, Zhi-Ming, Gong, Peng, Zhang, Bo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031075/
https://ncbi.nlm.nih.gov/pubmed/24852307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002891
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