Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3

The nonstructural protein NS3 from the Flaviviridae family is a multifunctional protein that contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral polyprotein processing and genome replication. Here we report a full-length crystal structure of the classical swin...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zheng, Fengwei, Lu, Guoliang, Li, Ling, Gong, Peng, Pan, Zishu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5640827/
https://ncbi.nlm.nih.gov/pubmed/28835495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01094-17
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