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Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3
The nonstructural protein NS3 from the Flaviviridae family is a multifunctional protein that contains an N-terminal protease and a C-terminal helicase, playing essential roles in viral polyprotein processing and genome replication. Here we report a full-length crystal structure of the classical swin...
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| Udgivet i: | J Virol |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5640827/ https://ncbi.nlm.nih.gov/pubmed/28835495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01094-17 |
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