Autocatalytic Cleavage within Classical Swine Fever Virus NS3 Leads to a Functional Separation of Protease and Helicase

Classical swine fever virus (CSFV) is a positive-stranded RNA virus belonging to the genus Pestivirus within the Flaviviridae family. Pivotal for processing of a large portion of the viral polyprotein is a serine protease activity within nonstructural protein 3 (NS3) that also harbors helicase and N...

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Main Authors: Lamp, Benjamin, Riedel, Christiane, Wentz, Eveline, Tortorici, Maria-Alejandra, Rümenapf, Till
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Genome Replication and Regulation of Viral Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3807365/
https://ncbi.nlm.nih.gov/pubmed/23986594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00754-13
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