Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase

Hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses multiple enzyme activities. The N-terminal one-third of NS3 primarily functions as a serine protease, while the remaining two-thirds of NS3 serve as a helicase and nucleoside triphosphatase. Whether the multiple enzyme activities of NS3...

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Autori principali: Zhang, Chen, Cai, Zhaohui, Kim, Young-Chan, Kumar, Ranjith, Yuan, Fenghua, Shi, Pei-Yong, Kao, Cheng, Luo, Guangxiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1168731/
https://ncbi.nlm.nih.gov/pubmed/15994762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.14.8687-8697.2005
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