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Regulation of De Novo-Initiated RNA Synthesis in Hepatitis C Virus RNA-Dependent RNA Polymerase by Intermolecular Interactions

The hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) has been proposed to change conformations in association with RNA synthesis and to interact with cellular proteins. In vitro, the RdRp can initiate de novo from the ends of single-stranded RNA or extend a primed RNA template. The intera...

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Detalhes bibliográficos
Main Authors: Chinnaswamy, S., Murali, A., Li, P., Fujisaki, K., Kao, C. C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876623/
https://ncbi.nlm.nih.gov/pubmed/20375156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02446-09
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