Intramolecular and Intermolecular Uridylylation by Poliovirus RNA-Dependent RNA Polymerase

The 22-amino-acid protein VPg can be uridylylated in solution by purified poliovirus 3D polymerase in a template-dependent reaction thought to mimic primer formation during RNA amplification in infected cells. In the cell, the template used for the reaction is a hairpin RNA termed 2C-cre and, possib...

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Detalhes bibliográficos
Main Authors: Richards, Oliver C., Spagnolo, Jeannie F., Lyle, John M., Vleck, Susan E., Kuchta, Robert D., Kirkegaard, Karla
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1563691/
https://ncbi.nlm.nih.gov/pubmed/16840321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02533-05
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