Allosteric Effects of Ligands and Mutations on Poliovirus RNA-Dependent RNA Polymerase

Protein priming of viral RNA synthesis plays an essential role in the replication of picornavirus RNA. Both poliovirus and coxsackievirus encode a small polypeptide, VPg, which serves as a primer for addition of the first nucleotide during synthesis of both positive and negative strands. This study...

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Detalhes bibliográficos
Main Authors: Boerner, Joanna E., Lyle, John M., Daijogo, Sarah, Semler, Bert L., Schultz, Stephen C., Kirkegaard, Karla, Richards, Oliver C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143668/
https://ncbi.nlm.nih.gov/pubmed/15919933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.12.7803-7811.2005
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