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Poliovirus cis-Acting Replication Element-Dependent VPg Uridylylation Lowers the K(m) of the Initiating Nucleoside Triphosphate for Viral RNA Replication
Initiation of RNA synthesis by RNA-dependent RNA polymerases occurs when a phosphodiester bond is formed between the first two nucleotides in the 5′ terminus of product RNA. The concentration of initiating nucleoside triphosphates (NTPi) required for RNA synthesis is typically greater than the conce...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2546976/ https://ncbi.nlm.nih.gov/pubmed/18653453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00427-08 |
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