Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has emerged as the pathologic trigger, transcriptional dysfunction may contribute to the neurodegeneration observed in HD. Pharmacological tr...

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Foilsithe in:J Neurosci
Main Authors: Ferrante, Robert J., Kubilus, James K., Lee, Junghee, Ryu, Hoon, Beesen, Ayshe, Zucker, Birgit, Smith, Karen, Kowall, Neil W., Ratan, Rajiv R., Luthi-Carter, Ruth, Hersch, Steven M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Society for Neuroscience 2003
Ábhair:
Cellular/Molecular
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740577/
https://ncbi.nlm.nih.gov/pubmed/14561870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-28-09418.2003
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