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Therapeutic Effects of Cystamine in a Murine Model of Huntington's Disease
The precise cause of neuronal death in Huntington's disease (HD) is unknown. Proteolytic products of the huntingtin protein can contribute to toxic cellular aggregates that may be formed in part by tissue transglutaminase (Tgase). Tgase activity is increased in HD brain. Treatment in R6/2 trans...
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| Pubblicato in: | J Neurosci |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6757687/ https://ncbi.nlm.nih.gov/pubmed/12388601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-20-08942.2002 |
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