Therapeutic Effects of Cystamine in a Murine Model of Huntington's Disease

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Proteolytic products of the huntingtin protein can contribute to toxic cellular aggregates that may be formed in part by tissue transglutaminase (Tgase). Tgase activity is increased in HD brain. Treatment in R6/2 trans...

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Pubblicato in:J Neurosci
Autori principali: Dedeoglu, Alpaslan, Kubilus, James K., Jeitner, Thomas M., Matson, Samantha A., Bogdanov, Misha, Kowall, Neil W., Matson, Wayne R., Cooper, Arthur J. L., Ratan, Rajiv R., Beal, M. Flint, Hersch, Steven M., Ferrante, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757687/
https://ncbi.nlm.nih.gov/pubmed/12388601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-20-08942.2002
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