Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has emerged as the pathologic trigger, transcriptional dysfunction may contribute to the neurodegeneration observed in HD. Pharmacological tr...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Ferrante, Robert J., Kubilus, James K., Lee, Junghee, Ryu, Hoon, Beesen, Ayshe, Zucker, Birgit, Smith, Karen, Kowall, Neil W., Ratan, Rajiv R., Luthi-Carter, Ruth, Hersch, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2003
Fag:
Cellular/Molecular
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740577/
https://ncbi.nlm.nih.gov/pubmed/14561870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-28-09418.2003
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