Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has emerged as the pathologic trigger, transcriptional dysfunction may contribute to the neurodegeneration observed in HD. Pharmacological tr...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ferrante, Robert J., Kubilus, James K., Lee, Junghee, Ryu, Hoon, Beesen, Ayshe, Zucker, Birgit, Smith, Karen, Kowall, Neil W., Ratan, Rajiv R., Luthi-Carter, Ruth, Hersch, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740577/
https://ncbi.nlm.nih.gov/pubmed/14561870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-28-09418.2003
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