Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

The precise cause of neuronal death in Huntington's disease (HD) is unknown. Although no single specific protein-protein interaction of mutant huntingtin has emerged as the pathologic trigger, transcriptional dysfunction may contribute to the neurodegeneration observed in HD. Pharmacological tr...

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Vydáno v:J Neurosci
Hlavní autoři: Ferrante, Robert J., Kubilus, James K., Lee, Junghee, Ryu, Hoon, Beesen, Ayshe, Zucker, Birgit, Smith, Karen, Kowall, Neil W., Ratan, Rajiv R., Luthi-Carter, Ruth, Hersch, Steven M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2003
Témata:
Cellular/Molecular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740577/
https://ncbi.nlm.nih.gov/pubmed/14561870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-28-09418.2003
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