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Prostaglandin E(2) Activates the Histaminergic System via the EP(4) Receptor to Induce Wakefulness in Rats

Prostaglandin (PG)E(2) promotes the wakeful state when administered into the posterior hypothalamus, in which the histaminergic tuberomammillary nucleus (TMN) is located. To explore the neurotransmitter mechanisms responsible for PGE(2)-induced wakefulness in rats, we examined the effect of PGE(2) o...

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Publicat a:J Neurosci
Autors principals: Huang, Zhi-Li, Sato, Yo, Mochizuki, Takatoshi, Okada, Tetsuya, Qu, Wei-Min, Yamatodani, Atsushi, Urade, Yoshihiro, Hayaishi, Osamu
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740344/
https://ncbi.nlm.nih.gov/pubmed/12853415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-14-05975.2003
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