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Reshuffling yeast chromosomes with CRISPR/Cas9
Genome engineering is a powerful approach to study how chromosomal architecture impacts phenotypes. However, quantifying the fitness impact of translocations independently from the confounding effect of base substitutions has so far remained challenging. We report a novel application of the CRISPR/C...
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| Publié dans: | PLoS Genet |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Public Library of Science
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6738639/ https://ncbi.nlm.nih.gov/pubmed/31465441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008332 |
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