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Chromosome engineering in zygotes with CRISPR/Cas9

Deletions, duplications, and inversions of large genomic regions covering several genes are an important class of disease causing variants in humans. Modeling these structural variants in mice requires multistep processes in ES cells, which has limited their availability. Mutant mice containing smal...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genesis
Prif Awduron: Boroviak, Katharina, Doe, Brendan, Banerjee, Ruby, Yang, Fengtang, Bradley, Allan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4819711/
https://ncbi.nlm.nih.gov/pubmed/26742453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.22915
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