Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes

Metabolism alters markedly with advancing gestation, characterized by progressive insulin resistance, dyslipidemia, and raised serum bile acids. The nuclear receptor farnesoid X receptor (FXR) has an integral role in bile acid homeostasis and modulates glucose and lipid metabolism. FXR is known to b...

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Udgivet i:Am J Physiol Endocrinol Metab
Main Authors: McIlvride, Saraid, Nikolova, Vanya, Fan, Hei Man, McDonald, Julie A. K., Wahlström, Annika, Bellafante, Elena, Jansen, Eugene, Adorini, Luciano, Shapiro, David, Jones, Peter, Marchesi, Julian R., Marschall, Hanns-Ulrich, Williamson, Catherine
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732461/
https://ncbi.nlm.nih.gov/pubmed/31237448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00407.2018
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