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Bile acids and their respective conjugates elicit different responses in neonatal cardiomyocytes: role of Gi protein, muscarinic receptors and TGR5

Bile acids are recognised as bioactive signalling molecules. While they are known to influence arrhythmia susceptibility in cholestasis, there is limited knowledge about the underlying mechanisms. To delineate mechanisms underlying fetal heart rhythm disturbances in cholestatic pregnancy, we used FR...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ibrahim, Effendi, Diakonov, Ivan, Arunthavarajah, Dulasi, Swift, Teresa, Goodwin, Mary, McIlvride, Saraid, Nikolova, Vanya, Williamson, Catherine, Gorelik, Julia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940781/
https://ncbi.nlm.nih.gov/pubmed/29740092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25569-4
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