Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulators of glucose metabolism, and FXR activity i...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bellafante, Elena, McIlvride, Saraid, Nikolova, Vanya, Fan, Hei Man, Manna, Luiza Borges, Chambers, Jenny, Machirori, Mavis, Banerjee, Anita, Murphy, Kevin, Martineau, Marcus, Schoonjans, Kristina, Marschall, Hanns-Ulrich, Jones, Peter, Williamson, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7359298/
https://ncbi.nlm.nih.gov/pubmed/32661285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67968-6
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