Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype

Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy-specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death. The endocrine signals that cause cholestasis are not known but 3α-sulfated progestero...

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Hlavní autoři: Abu-Hayyeh, Shadi, Papacleovoulou, Georgia, Lövgren-Sandblom, Anita, Tahir, Mehreen, Oduwole, Olayiwola, Jamaludin, Nurul Akmal, Ravat, Sabiha, Nikolova, Vanya, Chambers, Jenny, Selden, Clare, Rees, Myrddin, Marschall, Hanns-Ulrich, Parker, Malcolm G, Williamson, Catherine
Médium: Artigo
Jazyk:Inglês
Vydáno: Wiley Subscription Services, Inc., A Wiley Company 2013
Témata:
Autoimmune, Cholestatic and Biliary Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592994/
https://ncbi.nlm.nih.gov/pubmed/22961653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26055
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