Inhibition of Na(+)-Taurocholate Co-transporting Polypeptide-mediated Bile Acid Transport by Cholestatic Sulfated Progesterone Metabolites

Sulfated progesterone metabolite (P4-S) levels are raised in normal pregnancy and elevated further in intrahepatic cholestasis of pregnancy (ICP), a bile acid-liver disorder of pregnancy. ICP can be complicated by preterm labor and intrauterine death. The impact of P4-S on bile acid uptake was studi...

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Detalhes bibliográficos
Main Authors: Abu-Hayyeh, Shadi, Martinez-Becerra, Pablo, Sheikh Abdul Kadir, Siti H., Selden, Clare, Romero, Marta R., Rees, Myrddin, Marschall, Hanns-Ulrich, Marin, Jose J. G., Williamson, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2878045/
https://ncbi.nlm.nih.gov/pubmed/20177056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.072140
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