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Intrahepatic Cholestasis of Pregnancy Levels of Sulfated Progesterone Metabolites Inhibit Farnesoid X Receptor Resulting in a Cholestatic Phenotype

Intrahepatic cholestasis of pregnancy (ICP) is the most prevalent pregnancy-specific liver disease and is associated with an increased risk of adverse fetal outcomes, including preterm labor and intrauterine death. The endocrine signals that cause cholestasis are not known but 3α-sulfated progestero...

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Detalhes bibliográficos
Main Authors: Abu-Hayyeh, Shadi, Papacleovoulou, Georgia, Lövgren-Sandblom, Anita, Tahir, Mehreen, Oduwole, Olayiwola, Jamaludin, Nurul Akmal, Ravat, Sabiha, Nikolova, Vanya, Chambers, Jenny, Selden, Clare, Rees, Myrddin, Marschall, Hanns-Ulrich, Parker, Malcolm G, Williamson, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592994/
https://ncbi.nlm.nih.gov/pubmed/22961653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26055
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