Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes

Metabolism alters markedly with advancing gestation, characterized by progressive insulin resistance, dyslipidemia, and raised serum bile acids. The nuclear receptor farnesoid X receptor (FXR) has an integral role in bile acid homeostasis and modulates glucose and lipid metabolism. FXR is known to b...

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Publicado en:Am J Physiol Endocrinol Metab
Autores principales: McIlvride, Saraid, Nikolova, Vanya, Fan, Hei Man, McDonald, Julie A. K., Wahlström, Annika, Bellafante, Elena, Jansen, Eugene, Adorini, Luciano, Shapiro, David, Jones, Peter, Marchesi, Julian R., Marschall, Hanns-Ulrich, Williamson, Catherine
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6732461/
https://ncbi.nlm.nih.gov/pubmed/31237448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00407.2018
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