TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

The microglial receptors, CD33 and TREM2, have been associated with risk for Alzheimer’s disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that knock-out of CD33 attenuated amyloid beta (Aβ) pathology and improved cognition in 5xFAD mice, both of which were abrogated by...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neuron
Hlavní autoři: Griciuc, Ana, Patel, Shaun, Federico, Anthony N., Choi, Se Hoon, Innes, Brendan J., Oram, Mary K., Cereghetti, Gea, McGinty, Danielle, Anselmo, Anthony, Sadreyev, Ruslan I., Hickman, Suzanne E., Khoury, Joseph El, Colonna, Marco, Tanzi, Rudolph E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728215/
https://ncbi.nlm.nih.gov/pubmed/31301936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.06.010
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky