TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease

The microglial receptors, CD33 and TREM2, have been associated with risk for Alzheimer’s disease (AD). Here, we investigated crosstalk between CD33 and TREM2. We showed that knock-out of CD33 attenuated amyloid beta (Aβ) pathology and improved cognition in 5xFAD mice, both of which were abrogated by...

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Publicat a:Neuron
Autors principals: Griciuc, Ana, Patel, Shaun, Federico, Anthony N., Choi, Se Hoon, Innes, Brendan J., Oram, Mary K., Cereghetti, Gea, McGinty, Danielle, Anselmo, Anthony, Sadreyev, Ruslan I., Hickman, Suzanne E., Khoury, Joseph El, Colonna, Marco, Tanzi, Rudolph E.
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6728215/
https://ncbi.nlm.nih.gov/pubmed/31301936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2019.06.010
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