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Inhibitors of inosine 5′-monophosphate dehydrogenase as emerging new generation antimicrobial agents
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a vital enzyme involved in the de novo synthesis of guanine nucleotides. IMPDH catalyzes a crucial step of converting IMP into XMP that is further converted into GMP. Microbial infections rely on the rapid proliferation of bacteria, and this requires...
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| 出版年: | Medchemcomm |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Royal Society of Chemistry
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6727467/ https://ncbi.nlm.nih.gov/pubmed/31534651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00179d |
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