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Inhibitors of inosine 5′-monophosphate dehydrogenase as emerging new generation antimicrobial agents

Inosine 5′-monophosphate dehydrogenase (IMPDH) is a vital enzyme involved in the de novo synthesis of guanine nucleotides. IMPDH catalyzes a crucial step of converting IMP into XMP that is further converted into GMP. Microbial infections rely on the rapid proliferation of bacteria, and this requires...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Medchemcomm
Prif Awduron: Juvale, Kapil, Shaik, Althaf, Kirubakaran, Sivapriya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727467/
https://ncbi.nlm.nih.gov/pubmed/31534651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00179d
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