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Inhibitors of inosine 5′-monophosphate dehydrogenase as emerging new generation antimicrobial agents
Inosine 5′-monophosphate dehydrogenase (IMPDH) is a vital enzyme involved in the de novo synthesis of guanine nucleotides. IMPDH catalyzes a crucial step of converting IMP into XMP that is further converted into GMP. Microbial infections rely on the rapid proliferation of bacteria, and this requires...
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| Published in: | Medchemcomm |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Royal Society of Chemistry
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6727467/ https://ncbi.nlm.nih.gov/pubmed/31534651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00179d |
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