Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resulting in suppression of Wnt signaling. Here, we describe the development of NOTUM inhibitors that restore Wnt signaling for use in in vitro disease models where NOTUM over activity is an...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:Medchemcomm
Glavni autori: Atkinson, Benjamin N., Steadman, David, Zhao, Yuguang, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R., Jeganathan, Fiona, Lines, Georgie, Frew, Sarah, Monaghan, Amy, Kjær, Svend, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2019
Teme:
Chemistry
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727465/
https://ncbi.nlm.nih.gov/pubmed/31534655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00096h
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items