Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen

NOTUM is a carboxylesterase that has been shown to act by mediating the O-depalmitoleoylation of Wnt proteins resulting in suppression of Wnt signaling. Here, we describe the development of NOTUM inhibitors that restore Wnt signaling for use in in vitro disease models where NOTUM over activity is an...

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Wydane w:Medchemcomm
Główni autorzy: Atkinson, Benjamin N., Steadman, David, Zhao, Yuguang, Sipthorp, James, Vecchia, Luca, Ruza, Reinis R., Jeganathan, Fiona, Lines, Georgie, Frew, Sarah, Monaghan, Amy, Kjær, Svend, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Format: Artigo
Język:Inglês
Wydane: Royal Society of Chemistry 2019
Hasła przedmiotowe:
Chemistry
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6727465/
https://ncbi.nlm.nih.gov/pubmed/31534655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00096h
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