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NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition
Activation of Wnt signaling due to Wnt overexpression or mutations of Wnt pathway components is associated with various cancers. Blocking Wnt secretion by inhibiting PORCN enzymatic activity has shown efficacy in a subset of cancers with elevated Wnt signaling. Predicting response to upstream Wnt in...
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| Publicado no: | Oncotarget |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914292/ https://ncbi.nlm.nih.gov/pubmed/26848981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7157 |
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