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Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis

Activating mutations in the Wnt pathway drive a variety of cancers, but the specific targets and pathways activated by Wnt ligands are not fully understood. To bridge this knowledge gap, we performed a comprehensive time-course analysis of Wnt-dependent signaling pathways in an orthotopic model of W...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Madan, Babita, Harmston, Nathan, Nallan, Gahyathiri, Montoya, Alex, Faull, Peter, Petretto, Enrico, Virshup, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6264740/
https://ncbi.nlm.nih.gov/pubmed/30300142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI122383
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