Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation

BACKGROUND: Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized. METHODS:...

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Vydáno v:Genome Med
Hlavní autoři: Liu, Shiyang, Harmston, Nathan, Glaser, Trudy Lee, Wong, Yunka, Zhong, Zheng, Madan, Babita, Virshup, David M., Petretto, Enrico
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7580003/
https://ncbi.nlm.nih.gov/pubmed/33092630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-020-00788-5
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