Structural basis of the differential binding of engineered knottins to integrins αVβ3 and α5β1

Targeting both integrins αVβ3 and α5β1 simultaneously appears to be more effective in cancer therapy than targeting each one alone. The structural requirements for bispecific binding of ligand to integrins has not been fully elucidated. RGD-containing knottin 2.5F binds selectively to αVβ3 and α5β1,...

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Veröffentlicht in:Structure
Hauptverfasser: Van Agthoven, Johannes F., Shams, Hengameh, Cochran, Frank V., Alonso, José L., Kintzing, James R., Garakani, Kiavash, Adair, Brian D., Xiong, Jian-Ping, Mofrad, Mohammad R. K., Cochran, Jennifer R., Arnaout, M. Amin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726563/
https://ncbi.nlm.nih.gov/pubmed/31353240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.06.011
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